Cannabis and its role in controlling epilepsy and seizures
This information has been adapted from the Granny Storm Crow’s list.
Marijuana and Epilepsy (anecdotal- no date) www.rxmarihuana.com/epilepsy.htm
Anti-epileptic Action of Marijuana-Active Substances (full – 1949) www.onlinepot.org/medical/Dr_Tods_PDFs/s3_6.pdf
Anticonvulsant nature of marihuana smoking. (abst – 1975)
www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=39 320
Anticonvulsant activity of four oxygenated cannabidiol derivatives. (abst – 1975)
www.ncbi.nlm.nih.gov/pubmed/1188178
Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. (full – 1977)
jpet.aspetjournals.org/content/201/1/26.abstract?ijkey=8457ace5313942358e64d156c12d04bd3c7d5f21&keytype2=tf_ipsecsha
Anticonvulsant Action of Cannabis in the Rat: Role of Brain Monoamines.
(abst – 1978) www.ncbi.nlm.nih.gov/pubmed/104333
Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
(abst – 1980) www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=42
Antiepileptic potential of cannabidiol analogs. (abst – 1981)
www.ncbi.nlm.nih.gov/pubmed/7298873
The cannabinoids as potential antiepileptics. (abst – 1981)
www.ncbi.nlm.nih.gov/pubmed/6975285
Hypnotic and Antiepileptic Effects of Cannabidiol (abst – 1981)
www.ncbi.nlm.nih.gov/pubmed/7028792
Anticonvulsant effects of the (-) and (+)isomers of cannabidiol and their dimethylheptyl homologs. (abst – 1982)
www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=7071126&dopt=abstractplus
Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice. (abst – 1982) www.ncbi.nlm.nih.gov/pubmed/6129147
ILLICIT DRUG USE AND THE RISK OF NEW-ONSET SEIZURES
(abst – 1990)
aje.oxfordjournals.org/content/132/1/47.abstract?sid=9fd403c4-2e6e-4df4-a57c-208434b8ad0a
Marijuana use and the risk of new onset seizures. (full – 1992)
www.ncbi.nlm.nih.gov/pmc/articles/PMC2376682/?tool=pmcentrez
Treatment with CBD in oily solution of drug-resistant paediatric epilepsies.
(full – 2001) www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=173&&search_pattern=EPILEPSY
Therapeutic Aspects of Cannabis and Cannabinoids (full – 2001)
bjp.rcpsych.org/cgi/reprint/178/2/107.pdf
Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. (abst – 2001) www.ncbi.nlm.nih.gov/pubmed/11442148 321
Alcohol and marijuana: effects on epilepsy and use by patients with epilepsy.
(abst – 2001) www.ncbi.nlm.nih.gov/pubmed/11737161
The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy (full – 2003)
jpet.aspetjournals.org/content/307/1/129.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=160&resourcetype=HWCIT
Experiences with THC-treatment in children and adolescents (abst – 2003)
www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=80
On the application of cannabis in paediatrics and epileptology. (abst – 2003)
www.ncbi.nlm.nih.gov/pubmed/15159680
Cannabis may help epileptics (news – 2003) www.medicalnewstoday.com/articles/4423.php
Cannabis ‘could help epileptics’ (news – 2003) news.bbc.co.uk/2/hi/health/3162000.stm
Marijuana Use More Prevalent With Epilepsy (needs free registration)
(news – 2003) www.medscape.com/viewarticle/465891
Endocannabinoids and Their Implications for Epilepsy (full – 2004)
www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1176361&tool=pmcentrez
Cannabinoids: Defending the Epileptic Brain (full – 2004)
www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332/?tool=pmcentrez
Marijuana use and epilepsy – Prevalence in patients of a tertiary care epilepsy center (abst – 2004)
www.neurology.org/cgi/content/abstract/62/11/2095?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=marihuana&searchid=1&FIRSTINDEX=1760&resourcetype=HWCIT
Epilepsy patients are smoking pot (news – 2004) www.safeaccessnow.org/article.php?id=1638
Cannabinoids as potential anti-epileptic drugs. (abst – 2005)
www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=Retrieve&list_uids=16044663&dopt=abstractplus
Anandamide Induced Anti-Convulsion in an In Vitro Model of Epilepsy (abst – 2005)
www.kau.edu.sa/centers/spc/jkau/Doc/Med/12/Mada.pdf
Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid.
(abst – 2005) www.ncbi.nlm.nih.gov/pubmed/15461672
Not Too Excited? Thank Your Endocannabinoids (full – 2006)
www.sciencedirect.com/science/article/pii/S0896627306005927 322
Forebrain-Specific Inactivation of Gq/G11 Family G Proteins Results in Age-Dependent Epilepsy and Impaired Endocannabinoid Formation (full – 2006)
mcb.asm.org/cgi/content/full/26/15/5888?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=1360&resourcetype=HWCIT
The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus (full – 2006) www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341/?tool=pmcentrez
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy (full – 2006)
www.ncbi.nlm.nih.gov/pmc/articles/PMC1808496/?tool=pmcentrez
Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus (full – 2006)
jpet.aspetjournals.org/content/317/3/1072.full?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&searchid=1&FIRSTINDEX=320&resourcetype=HWCIT#ref-list-1
Arachidonyl-2′-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. (abst – 2006) www.ncbi.nlm.nih.gov/pubmed/16930590
Brain’s Cannabinoid System ‘Mellows’ Seizures (news – 2006)
www.sciencedaily.com/releases/2006/08/060817103710.htm
Brain’s cannabinoid system fights seizures (news – 2006) www.physorg.com/news75053658.html
Downregulation of the CB1 Cannabinoid Receptor and Related Molecular Elements of the Endocannabinoid System in Epileptic Human Hippocampus (full – 2007)
www.jneurosci.org/cgi/content/full/28/12/2976?maxtoshow=&hits=80&RESULTFORMAT=&fulltext=cannabinoid&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
Endocannabinoids block status epilepticus in cultured hippocampal neurons
(full – 2007) www.ncbi.nlm.nih.gov/pmc/articles/PMC2617750/?tool=pmcentrez
Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus (full – 2007) www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113/?tool=pmcentrez
Marijuana: an effective antiepileptic treatment in partial epilepsy? (abst – 2007)
www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=157
Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice. (abst – 2007) www.ncbi.nlm.nih.gov/pubmed/17870135 323
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. (full – 2008) www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/?tool=pubmed
The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice (abst – 2008) www.ncbi.nlm.nih.gov/pubmed/18502613
The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.
(full – 2009)
onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full
Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. (full – 2009) www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed
Effect of arachidonyl-2′-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model. (abst – 2009) www.ncbi.nlm.nih.gov/pubmed/19751793
Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice. (abst – 2009) www.ncbi.nlm.nih.gov/pubmed/19223154
Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo (full – 2010) www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/?tool=pmcentrez
Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy. (full – 2010)
www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed
AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. (full – 2010)
www.ncbi.nlm.nih.gov/pmc/articles/PMC3006205/?tool=pubmed
Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats. (abst – 2010) www.ncbi.nlm.nih.gov/pubmed/20196794
Anticonvulsant effects of GWP42006 in vitro and in vivo in rat (abst – 2010)
www.physoc.org/custom2/publications/proceedings/archive/article.asp?ID=Proc%20Physiol%20Soc%2019C117
Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans. (abst – 2010) www.ncbi.nlm.nih.gov/pubmed/20618415 324
Endocannabinoid system protects against cryptogenic seizures. (full – 2011)
www.if-pan.krakow.pl/pjp/pdf/2011/1_165.pdf
Convulsions Associated with the Use of a Synthetic Cannabinoid Product. (full – 2011)
www.springerlink.com/content/9651q2672027n38g/fulltext.html
Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy. (abst – 2011) www.ncbi.nlm.nih.gov/pubmed/21733658
Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice. (abst – 2011)
www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_55212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maximal_electroshock_induced_seizures_in_mice_
Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy (abst – 2011)
www.unboundmedicine.com/medline/ebm/record/21469332/abstract/%5BProtective_effects_of_CB1_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lobe_epilepsy%5D_
L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure. (abst – 2011) www.ncbi.nlm.nih.gov/pubmed/21928146
Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures. (abst – 2011) www.ncbi.nlm.nih.gov/pubmed/22079489
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis. (abst – 2011) www.ncbi.nlm.nih.gov/pubmed/21303859
Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention. (abst – 2011) www.ncbi.nlm.nih.gov/pubmed/22178327
Cannabis could help treat epilepsy (news – 2011) www.newkerala.com/news/world/fullnews-186693.html
Cannabis could be used to treat epilepsy (news – 2011)
www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html
New research provides hope for those with epilepsy (news – 2011)
medicalxpress.com/news/2011-04-epilepsy.html
Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period. (abst – 2012) www.ncbi.nlm.nih.gov/pubmed/22019959
‘Hammer Head’ ‘incense’ blamed for seizure of youth in Le Roy (news – 2012)
thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983 325
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